anguish

Definition:

The term "anguish" refers to severe pain or distress.

Anguish can be physical or emotional pain or distress.
Often people who are in extreme anguish will show it in their face and behaviors.
For example, a person in severe pain or anguish might grit his teeth or cry out.
The term "anguish" could also be translated as, "emotional distress" or "deep sorrow" or "severe pain."