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Flee youthful lusts
Paul speaks about youthful lusts as if they are a dangerous person or animal that Timothy should run away from. AT: "Completely avoid youthful lusts" or "Absolutely refuse to do the wrong things that young people strongly desire to do" (See: rc://en/ta/man/translate/figs-metaphor)
Pursue righteousness
Here "Pursue" means the opposite of "Flee." Paul speaks of righteousness as if it is an object that Timothy should run towards because it will do him good. AT: "Try your best to obtain righteousness" or "Seek after righteousness" (See: rc://en/ta/man/translate/figs-metaphor)
with those
Possible meanings are 1) Paul wants Timothy to join with other believers in pursuing righteousness, faith, love, and peace, or 2) Paul wants Timothy to be at peace and not argue with other believers.
those who call on the Lord
Here "call on the Lord" is an idiom that means to trust and worship the Lord. AT: "those who worship the Lord" (See: rc://en/ta/man/translate/figs-idiom)
out of a clean heart
"Heart" here is a metonym for "thoughts and intentions." AT: "from right thoughts and good intentions" (See: rc://en/ta/man/translate/figs-metonymy)
refuse foolish and ignorant questions
"refuse to answer foolish and ignorant questions." Paul means that the people who ask such questions are foolish and ignorant. AT: "refuse to answer the questions that foolish people who do not want to know the truth ask" (See: rc://en/ta/man/translate/figs-metonymy)
they give birth to arguments
Paul speaks of ignorant questions as if they were women giving birth to children. AT: "they cause arguments" (See: rc://en/ta/man/translate/figs-metaphor)