profane

Definition

To profane something means to act in a way that defiles, pollutes, or disrespects something that is holy.

The holy thing or person does not become unholy; rather it is treated in a way that is irreverent and unholy.
A profane person is one who acts in a way that is unholy and dishonoring of God.
The verb "to profane" could be translated as "to treat as unholy", "to be irreverent toward", or "to dishonor God (by sinning)."
Depending on the context, the word "profane" as an adjective could be translated as "irreverent" or "godless" or "unholy."