profane

Definition

To profane something means to act in a way that defiles, pollutes, or disrespects something that is holy.

The holy thing or person does not become unholy; rather it is treated in a way that is irreverent and unholy.
A profane person is one who acts in a way that is unholy and dishonoring of God.
The verb "to profane" could be translated as "to treat as unholy", "to be irreverent toward", or "to dishonor God