General Information:

This verse is a break from John's account of his vision. Here he gives another warning to the people reading his account.

This calls for wisdom

"Wisdom is needed" or "You need to be wise about this"

The word "insight" can be translated with the verb "understand." AT: "If anyone is able to understand things" (See: rc://en/ta/man/translate/figs-abstractnouns)

"he should discern what the number of the beast means" or "he should figure out what the number of the beast means"

Possible meanings are 1) the number represents one person or 2) the number represents all of humanity.