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With every prayer and request, pray at all times in the Spirit

"Pray at all times in the Spirit as you pray and make specific requests"

To this end

"For this reason" or "Keeping this in mind." This refers to the attitude of taking God's armor.

be watching with all perseverance as you offer prayers for all God's holy people

"be watching, and even when it is difficult, keep praying for all the believers "