Paul uses "always" as a generalization meaning "often" or "regularly. The sentence emphasizes the greatness of what God is doing in the lives of the Thessalonian believers. Alternate translation: "We should often give thanks to God" (See: [[rc://en/ta/man/translate/figs-hyperbole]])
Here "brothers" means fellow Christians, including both men and women. Alternate translation: "brothers and sisters" (See: [[rc://en/ta/man/translate/figs-gendernotations]])