The priests and prophets are spoken of as if they were blind because they wandered through the streets, not knowing where to go. Alternate translation: "They wandered through the streets like blind men" (See: [[rc://en/ta/man/translate/figs-metaphor]])
Here "defiled" represents being unacceptable to God. Because the priests and prophets murdered people, they were ritually unclean, unable to worship God or be with ordinary people. (See: [[rc://en/ta/man/translate/figs-metaphor]])
# defiled by that blood
"defiled by the blood that they shed." Possible meanings are 1) the blood was on their clothes or 2) "blood" is a metonym for murder. (See: [[rc://en/ta/man/translate/figs-metonymy]])