These are both metaphors for living the Christian life and serving God by working as hard as one can to succeed and so gain something good and to avoid failing and so losing something good. (See: [[rc://en/ta/man/jit/figs-metaphor]])
If this double negative would confuse the reader in your language, you can state it as a simple positive. Alternate translation: "run: with purpose" (See: [[:en:ta:vol2:translate:figs_doublenegatives]])
# box
to beat another person with the fists in a sporting contest