This compares their many sins to something very heavy that a person might carry. Alternate translation: "their sin is like a heavy bag on their shoulders that makes it hard for them to walk." (See: [[rc://en/ta/man/translate/figs-metaphor]])
## They have abandoned Yahweh ##
"They have turned away from Yahweh"
## they have despised the Holy One of Israel ##
"they have rejected the Holy One of Israel" or "they have been disrespectful to the Holy One of Israel"
## they have estranged themselves from him ##
"they have separated themselves from him." Alternate translation: "they have treated him as a stranger."