This rhetorical question is a rebuke. It can be translated as a statement. AT: "You should not scorn my sacrifices ... where I live." (See: [[rc://en/ta/man/translate/figs-rquestion]])
The word "house" is a metonym for the people who lived in the house. See how you translated this in [1 Samuel 2:27](./27.md). AT: "the family of your ancestor" (See: [[rc://en/ta/man/translate/figs-metonymy]])
The words "lightly esteemed" is an ironic euphemism for "greatly despised." This can be stated in active form. AT: "I will lightly esteem those who despise me" or "I will greatly despise those who despise me" (See: [[rc://en/ta/man/translate/figs-irony]] and [[rc://en/ta/man/translate/figs-euphemism]] and [[rc://en/ta/man/translate/figs-activepassive]])