## May the grace of our Lord Jesus Christ be with your spirit. ##
This can be translated as "May our Lord Jesus Christ be kind to your spirit."
## your spirit ##
The word "your" here refers to Philemon and all who met in his house. The word "spirit" here refers to the whole person; The phrase can be translated as "you." (See: [[rc://en/ta/man/translate/figs-synecdoche]] and [[rc://en/ta/man/translate/figs-you]])